Our research at MGH

  • Melonakos ED, Siegmann MJ, Rey C, O’Brien C, Nikolaeva KK, Solt K, Nehs CJ. Excitation of Putative Glutamatergic Neurons in the Rat Parabrachial Nucleus Region Reduces Delta Power during Dexmedetomidine but not Ketamine Anesthesia. Anesthesiology.  2021 Oct 1;135(4):633-648. PMID: 34270686, PMCID: PMC8440361 (available on 2022-10-01)

  • Kato R, Zhang ER, Mallari O, Moody O, Vincent K, Melonakos ED, Siegmann MJ, Nehs CJ, Houle TT, Akeju O, Solt K. D-Amphetamine Rapidly Reverses Dexmedetomidine-Induced Unconsciousness in Rats. Front Pharmacol. 2021 May 18;12:668285. doi: 10.3389/fphar.2021.668285. PMID: 34084141, PMCID: PMC8167047

  • Moody O, Zhang ER, Vincent KF, Kato R, Melonakos ED, Nehs CJ, Solt K. The Neural Circuits Underlying General Anesthesia and Sleep. Anesthesia & Analgesia 2021 May 1;132(5):1254-1264. PMID: 33857967, PMCID: PMC8054915 (available on 2022-05-01)

  • Vlasov KY, Pei J, Nehs CJ, Guidera JA, Zhang ER, Kenny JD, Houle TT, Brenner GJ, Taylor NE, Solt K. Activation of GABAergic Neurons in the Rostromedial Tegmental Nucleus and Other Brainstem Regions Promotes Sedation and Facilitates Sevoflurane Anesthesia in Mice. Anesthesia & Analgesia 132(4):e50-e55. PMID: 33560660 PMCID: PMC7969415 (available on 2022-04-01)

  • Melonakos ED, Moody OA, Nikolaeva K, Kato R, Nehs CJ, Solt K. Manipulating Neural Circuits in Anesthesia Research. Anesthesiology 133(1): 19-30, 2020. PMID: 32349073,  PMCID: PMC8351362

  • Taylor NE, Pei J, Zhang J, Vlasov KY, Davis T, Taylor E, Weng FJ, Van Dort CJ, Solt K, Brown EN. The Role of Glutamatergic and Dopaminergic Neurons in the Periaqueductal Gray/Dorsal Raphe: Separating Analgesia and Anxiety. eNeuro. 6(1) 2019. PMID: 31058210, PMCID: PMC6498422

  • Siegmann MJ, Athinarayanan SJ, Hallberg SJ, McKenzie AL, Bhanpuri NH, Campbell WW, McCarter JP, Phinney SD, Volek JS, Van Dort CJ. Improvement in patient-reported sleep in type 2 diabetes and prediabetes participants receiving a continuous care intervention with nutritional ketosis. Sleep Medicine 55:92-99, 2019. PMID: 30772699

  • Vlasov KY, Van Dort CJ, Solt K. Optogenetics and Chemogenetics. Methods in Enzymology: Special Issue on Anesthesiology. 603:181-196, 2018. PMID: 29673525

  • Zhang H, Zhao H, Zeng C, Van Dort C, Faingold CL, Taylor NE, Solt K, Feng HJ. Optogenetic activation of 5-HT neurons in the dorsal raphe suppresses seizure-induced respiratory arrest and produces anticonvulsant effect in the DBA/1 mouse SUDEP model. Neurobiol Dis 110: 47-58, 2018. PMID: 29141182, PMCID: PMC5748009

  • Taylor NE, Van Dort CJ, Kenny JD, Pei JZ, Guidera JA, Vlasov KY, Lee JT, Boyden ES, Brown EN, Solt K. Optogenetic Activation of Dopamine Neurons in the Ventral Tegmental Area Induces Reanimation from General Anesthesia. Proc Natl Acad Sci USA 113(45): 12826-12831, 2016. PMID: 27791160, PMCID: PMC5111696

  • Kenny JD, Chemali JJ, Cotton JF, Van Dort CJ, Kim SE, Ba D, Taylor, NE, Brown EN, Solt K. Physostigmine and Methylphenidate Induce Distinct Arousal States During Isoflurane General Anesthesia in Rats. Anesthesia & Analgesia 123(5):1210-1219, 2016. PMID: 26991753, PMCID: PMC5026857

  • Muindi F, Kenny JD, Taylor NE, Solt K, Wilson MA, Brown EN, Van Dort CJ. Electrical Stimulation of the Parabrachial Nucleus Induces Reanimation from Isoflurane General Anesthesia. Behavioral Brain Research 306: 20-25, 2016. PMID: 26971629

  • Van Dort CJ. Locus Coeruleus Neural Fatigue: A Potential Mechanism for Cognitive Impairment during Sleep Deprivation. Sleep 39(1): 11-12, 2016. PMID: 26564138, PMCID: PMC4678350

  • Van Dort CJ, Brown EN. Reply to Grace: Role of cholinergic neurons in rapid eye movement (REM) sleep control. Proc Natl Acad Sci USA 112(29): E3756, 2015. PMID: 26124152, PMCID: PMC4517216

  • Van Dort CJ, Zachs DP, Kenny JD, Zheng S, Goldblum RR, Gelwan NA, Ramos DM, Nolan MA, Wang K, Weng F, Lin Y, Wilson MA, Brown EN: Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep. Proc Natl Acad Sci USA 112: 584-589, 2015. PMID: 25548191, PMCID: PMC4299243

  • Solt K, Van Dort CJ, Chemali JJ, Taylor NE, Kenny JD, Brown EN. Electrical stimulation of the ventral tegmental area induces reanimation from general anesthesia. Anesthesiology 121: 311-319, 2014. PMID: 24398816, PMCID: PMC4112744

  • Chemali JJ, Van Dort CJ, Brown EN, Solt K. Active emergence from propofol general anesthesia is induced by methylphenidate. Anesthesiology 116: 998-1005, 2012. PMID: 22446983, PMCID: PMC3339625

  • Brown EN, Purdon PL, Van Dort CJ. General Anesthesia and Altered States of Arousal: A Systems Neuroscience Analysis. Annu Rev Neurosci 34: 601-628, 2011. PMID: 21513454, PMCID: PMC3390788

  • Van Dort CJ, Baghdoyan HA, Lydic R. Adenosine A1 and A2A receptors in mouse prefrontal cortex modulate acetylcholine release and behavioral arousal. J Neurosci 29: 871-881, 2009. PMID: 19158311, PMCID: PMC3430130

  • Van Dort CJ, Baghdoyan HA, Lydic R. Neurochemical Modulators of Sleep and Anesthetic States. Int Anesthesiol Clin 46: 75-104, 2008. PMID: 18617819, PMCID: PMC2745232

  • Buchwalter A, Van Dort C, Schultz S, Smith R, Le IP, Abbott JL, Oosterhouse E, Johnson AE, Hansen-Smith F, Burnatowska-Hledin M. Expression of VACM-1/cul5 mutant in endothelial cells induces MAPK phosphorylation and maspin degradation and converts cells to the angiogenic phenotype. Microvasc Res 75: 155-168, 2008. PMID: 17950367

  • Stanley KT, VanDort C, Motyl C, Endres J, Fox DA. Immunocompetent properties of human osteoblasts: interactions with T lymphocytes. J Bone Miner Res 21: 29-36, 2006. PMID: 16355271

  • Burnatowska-Hledin MA, Kossoris JB, Van Dort CJ, Shearer RL, Zhao P, Murrey DA, Abbott JL, Kan CE, Barney CC. T47D breast cancer cell growth is inhibited by expression of VACM-1, a cul-5 gene. Biochem Biophys Res Commun 319: 817-825, 2004. PMID: 15184056